Dong Kimberly, Quan David J
School of Pharmacy, University of California San Francisco, San Francisco, CA, USA.
Nephrol Nurs J. 2010 May-Jun;37(3):304-8.
Chronic kidney disease affects millions of Americans. Many drugs are eliminated from the body by the kidneys. As renal function declines due to the disease, drugs that are normally eliminated by the kidneys can accumulate, potentially leading to toxicity. Assessing kidney function in patients is essential in determining the appropriate dose of medications to achieve the desired clinical outcome while minimizing the potential for toxicity.
慢性肾脏病影响着数百万美国人。许多药物通过肾脏从体内排出。由于该疾病导致肾功能下降,通常经肾脏排出的药物会蓄积,可能导致毒性。评估患者的肾功能对于确定合适的药物剂量以实现预期临床效果并将潜在毒性降至最低至关重要。