Sulf-2：细胞信号传导的细胞外调节剂和癌症靶候选物。
Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate.
机构信息
University of California, Department of Anatomy and Comprehensive Cancer Center, San Francisco, 94143, USA.
出版信息
Expert Opin Ther Targets. 2010 Sep;14(9):935-49. doi: 10.1517/14728222.2010.504718.
Abstract
IMPORTANCE OF THE FIELD
Sulf-1 and Sulf-2 are sulfatases that edit the sulfation status of heparan sulfate proteoglycans (HSPGs) on the outside of cells and regulate a number of critical signaling pathways. The Sulfs are dysregulated in many cancers with Sulf-2 in particular implicated as a driver of carcinogenesis in NSCLC, pancreatic cancer and hepatocellular carcinoma.
AREAS COVERED IN THIS REVIEW
This review describes the novel activity of the Sulfs in altering the sulfation pattern of HSPG chains on the outside of cells. Thereby, the Sulfs can change the binding of growth factors to these chains and can either promote (e.g., Wnt) or inhibit (e.g., fibroblast growth factor-2) signaling. The review focuses on the widespread upregulation of both Sulfs in cancers and summarizes the evidence that Sulf-2 promotes the transformed behavior of several types of cancer cells in vitro as well as their tumorigenicity in vivo.
WHAT THE READER WILL GAIN
Sulf-2 is a bonafide candidate as a cancer-causing agent in NSCLC and other cancers in which it is upregulated.
TAKE HOME MESSAGE
Sulf-2 is an extracellular enzyme and as such would be an attractive therapeutic target for the treatment of NSCLC and other cancers.
摘要
重要性领域
Sulf-1 和 Sulf-2 是硫酸酯酶，可修饰细胞外的硫酸乙酰肝素蛋白聚糖 (HSPG) 的硫酸化状态，并调节许多关键的信号通路。Sulfs 在许多癌症中失调，特别是 Sulf-2 被认为是非小细胞肺癌、胰腺癌和肝癌发生的驱动因素。
本综述涵盖的领域
本综述描述了 Sulfs 在改变细胞外 HSPG 链的硫酸化模式方面的新活性。因此，Sulfs 可以改变生长因子与这些链的结合，从而促进（例如 Wnt）或抑制（例如成纤维细胞生长因子-2）信号。该综述重点介绍了 Sulfs 在癌症中的广泛上调，并总结了证据表明 Sulf-2 促进了几种类型的癌细胞在体外的转化行为以及它们在体内的致瘤性。
读者将获得什么
Sulf-2 是 NSCLC 和其他上调的癌症中致癌的真正候选者。
重要信息
Sulf-2 是一种细胞外酶，因此作为治疗 NSCLC 和其他癌症的治疗靶点具有吸引力。
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