Kupfer D J, Pollock B G, Perel J M, Jarrett D B, McEachran A B, Miewald J M
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213-2593.
Psychiatry Res. 1991 Mar;36(3):279-89. doi: 10.1016/0165-1781(91)90026-l.
An i.v. challenge dose of clomipramine (12.5 mg) was given to eight outpatients with major depression. The procedure facilitated the examination of all-night sleep and sleep-related neuroendocrine changes (cortisol, growth hormone, and prolactin). In comparison to baseline saline nights, the patients experienced a profound suppression of rapid eye movement (REM) sleep throughout the night with no rebound recovery in the second half of the night. Furthermore, REM-suppressing effects were noted on the following no-drug night. In contrast, little effect on delta wave sleep was found, except for increased consolidation of delta waves within stage 3 and 4 sleep. Delta sleep measures were significantly correlated with levels of cortisol and growth hormone.
对8名重度抑郁症门诊患者静脉注射氯米帕明激发剂量（12.5毫克）。该程序有助于检查整夜睡眠及与睡眠相关的神经内分泌变化（皮质醇、生长激素和催乳素）。与基线生理盐水注射的夜晚相比，患者整夜快速眼动（REM）睡眠受到显著抑制，下半夜无反弹恢复。此外，在接下来的无药物夜晚也观察到了REM抑制作用。相比之下，除了3期和4期睡眠中δ波巩固增加外，对δ波睡眠几乎没有影响。δ睡眠指标与皮质醇和生长激素水平显著相关。
