Klein E, Hefez A, Lavie P
Neuropsychobiology. 1984;11(2):85-8. doi: 10.1159/000118058.
Sleep structure of 10 endogenous depressed patients was investigated before and after clomipramine treatment. Clomipramine significantly reduced REM time, increased REM latency and induced dissociation between the tonic and phasic events of REM sleep, without affecting any of the other sleep parameters. The REM suppressing effect was most prominent on the third night after beginning treatment.
对10例内源性抑郁症患者在氯米帕明治疗前后的睡眠结构进行了研究。氯米帕明显著缩短了快速眼动（REM）睡眠时间，延长了REM潜伏期，并导致REM睡眠的紧张性和相位性事件之间出现分离，而不影响任何其他睡眠参数。REM抑制作用在开始治疗后的第三个晚上最为显著。
