Neurology Department, Wayne State University School of Medicine, Detroit, Michigan, USA.
Pain Pract. 2010 Jan-Feb;10(1):54-9. doi: 10.1111/j.1533-2500.2009.00334.x.
This study investigates the response of the underlying sleep disorder associated with Chronic Fatigue Syndrome (CFS) and fibromyalgia (FM) to treatment. We retrospectively reviewed 118 cases clinically consistent with CFS or FM, treated in a neurology practice. Abnormal findings on sleep studies and associated human leukocyte antigen markers, and a clinical pattern suggestive of narcolepsy, are present in a high proportion of patients. When considered appropriate based on the clinical picture and test results, treatment with sodium oxybate was offered to these patients. Sixty percent of patients treated with oxybate experienced significant relief of pain, while 75% experienced significant relief of fatigue. We postulate that the response to oxybate in CFS and FM suggests a disturbance of sleep similar to narcolepsy. These findings support this novel approach to intervention and further research. The inability to distinguish CFS and FM by testing and response to treatment suggests that they may represent variations of the same disorder or may be closely related disorders.
本研究旨在探讨与慢性疲劳综合征（CFS）和纤维肌痛（FM）相关的潜在睡眠障碍对治疗的反应。我们回顾性分析了在神经病学诊所就诊的 118 例临床符合 CFS 或 FM 的病例。睡眠研究中存在异常发现，以及相关的人类白细胞抗原标志物，且临床模式提示发作性睡病，在很大一部分患者中存在。根据临床表现和检查结果，当认为合适时，向这些患者提供羟丁酸钠治疗。接受羟丁酸钠治疗的患者中有 60%的疼痛显著缓解，75%的疲劳显著缓解。我们推测，CFS 和 FM 对羟丁酸钠的反应表明存在类似于发作性睡病的睡眠障碍。这些发现支持这种新的干预方法和进一步的研究。由于无法通过测试和治疗反应来区分 CFS 和 FM，这表明它们可能代表同一疾病的不同表现形式，或者可能是密切相关的疾病。
