Department of Cardiology, Westmead Hospital, Hawkesbury Road, Westmead, NSW 2145, Australia.
Heart Lung Circ. 2010 Jul;19(7):406-12. doi: 10.1016/j.hlc.2010.03.001.
Even in 'healthy' individuals, ageing alters left ventricular diastolic function with a decrease in early diastolic filling. There is a paucity of data with regards to right ventricular (RV) parameters with normal ageing. We sought to determine the effect of ageing on RV size and function in a group of 'healthy' individuals.
We retrospectively analysed echocardiograms from 60 healthy volunteers in three age groups (20-80 years) from a departmental database. RV area and volume were measured from the apical 4-chamber view and indexed to body surface area. Pulsed-wave tissue Doppler Imaging (TDI) was used to obtain right ventricular lateral annular systolic and diastolic velocities. Using Colour Doppler Tissue Imaging (CDTI), mean peak segmental velocities in systole (S') and in diastole (E', and A') were measured from the annular and mid-segments of the lateral RV. There was no change observed in RV area, volume or ejection fraction with increasing age. RV systolic function evaluated by RVEF and S' velocity were also unchanged with ageing. There was a significant decrease in CDTI and pulsed-wave TDI E' velocity with age (p<0.05) with a corresponding increase in A' velocity.
Normal ageing leads to impaired RV relaxation with a reduction in E' velocity and amplification of the atrial component (A') without a change in overall RV volume or systolic function.
即使在“健康”个体中，衰老也会改变左心室舒张功能，导致早期舒张充盈减少。关于正常衰老过程中右心室（RV）参数的数据很少。我们旨在确定年龄对一组“健康”个体的 RV 大小和功能的影响。
我们从一个部门数据库中回顾性地分析了来自三个年龄组（20-80 岁）的 60 名健康志愿者的超声心动图。从心尖 4 腔视图测量 RV 面积和容量，并按体表面积指数化。使用脉冲组织多普勒成像（TDI）获得右心室侧壁环的收缩和舒张速度。使用彩色多普勒组织成像（CDTI），从 RV 外侧的环状和中段测量收缩期（S'）和舒张期（E'和 A'）的平均节段峰值速度。随着年龄的增长，RV 面积、容量或射血分数没有观察到变化。通过 RVEF 和 S'速度评估的 RV 收缩功能也随年龄增长而保持不变。随着年龄的增长，CDTI 和脉冲 TDI E'速度显著下降（p<0.05），相应地 A'速度增加。
正常衰老导致 RV 舒张松弛受损，E'速度降低，心房成分（A'）放大，而整体 RV 容积或收缩功能没有变化。
