慢性心力衰竭贫血的介质。

Mediators of anemia in chronic heart failure.

机构信息

Tulane Heart and Vascular Institute, Tulane University School of Medicine, 1340 Tulane Avenue, SL-48, New Orleans, LA 70112, USA.

出版信息

Heart Fail Clin. 2010 Jul;6(3):289-93. doi: 10.1016/j.hfc.2010.03.008.

DOI:10.1016/j.hfc.2010.03.008

PMID:20630403

Abstract

Anemia is highly prevalent in patients with chronic heart failure (CHF) and is associated with poor clinical outcome. Increased prevalence of anemia in CHF has been linked to advanced age, female gender, renal function impairment, severity of symptoms, and clinical settings. Overall, the anemia of CHF shares many common features with the anemia of chronic disease. Both impaired iron metabolism and inflammatory stress appear to be the key mediators of the anemia of CHF.

摘要

贫血在慢性心力衰竭（CHF）患者中非常普遍，与不良临床结局相关。CHF 中贫血的患病率增加与年龄较大、女性、肾功能损害、症状严重程度和临床环境有关。总的来说，CHF 的贫血与慢性疾病的贫血有许多共同特征。铁代谢受损和炎症应激似乎都是 CHF 贫血的关键介质。