School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.
Res Vet Sci. 2011 Apr;90(2):284-7. doi: 10.1016/j.rvsc.2010.06.016. Epub 2010 Jul 13.
Post mortem liver samples from 12 donkeys (Equus asinus) aged 21-57 years (4 females, 1 stallion, 7 geldings), were assessed chemically for copper and iron content on a wet weight basis and histologically for stainable iron. Chemical liver copper content ranged from 2.7 to 4.8μg/g (mean 3.5±0.05μg/g). Chemical liver iron content ranged from 524 to 5010μg/g (mean 1723±1258μg/g). Histochemical iron was measured morphometrically using a computer-based image analysis system; percentage section area staining for iron ranged from 0.84% to 26.69% (mean 10.82±8.36%). There was no clear correlation, within the wide range of iron values, between histochemically demonstrable iron and chemically measured iron content. No clear age-related increase was apparent for either parameter in these aged donkeys. The accumulation of iron in the liver of donkeys may represent a physiological haemosiderosis rather than pathological haemochromatosis.
对 12 匹年龄在 21-57 岁的（4 匹母马、1 匹公马、7 匹去势马）驴死后的肝脏样本进行了化学检测，以湿重为基础评估了铜和铁的含量，并进行了可染色铁的组织学评估。化学法检测的肝脏铜含量范围为 2.7 至 4.8μg/g（平均值 3.5±0.05μg/g）。化学法检测的肝脏铁含量范围为 524 至 5010μg/g（平均值 1723±1258μg/g）。使用基于计算机的图像分析系统对组织化学铁进行了形态计量学测量；铁染色的组织面积百分比范围为 0.84%至 26.69%（平均值 10.82±8.36%）。在这些老龄驴的广泛铁值范围内，组织化学法检测的铁与化学法测量的铁含量之间没有明显的相关性。对于这两个参数，在这些老龄驴中，没有明显的与年龄相关的增加。驴肝脏中铁的积累可能代表生理性血铁沉着症，而不是病理性血色病。
