School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK.
Res Vet Sci. 2011 Apr;90(2):275-9. doi: 10.1016/j.rvsc.2010.05.033. Epub 2010 Jul 24.
Histopathological examination was carried out on post mortem samples of liver from 12 donkeys (Equus asinus), aged 21-57 years (4 females, 1 stallion, 7 geldings). Variable amounts of haemosiderin were present in Kupffer cells, portal macrophages and hepatocytes in all cases. In all cases there was infiltration of connective tissue around portal tracts by variable numbers of inflammatory cells (lymphocytes, plasma cells and macrophages) but obvious portal fibrosis was present in only four animals. Subjective assessment of overall haemosiderin staining (including extent and intensity) generally reflected biochemical measurements of liver iron content (measured by an inductively-coupled plasma method) as well as quantitative histochemical measurements (using an image analysis package and sections stained with Perl's Prussian blue stain). Accumulation of hepatic iron in old donkeys was not directly related to other pathological changes and may be an incidental finding.
对 12 匹（21-57 岁）年龄的驴（Equus asinus）死后的肝脏样本进行了组织病理学检查，结果显示在所有病例中库普弗细胞、门脉巨噬细胞和肝细胞中均存在不同程度的含铁血黄素。所有病例中，均有数量不等的炎症细胞（淋巴细胞、浆细胞和巨噬细胞）浸润门脉周围结缔组织，但仅有 4 只动物存在明显的门脉纤维化。对总体含铁血黄素染色（包括范围和强度）的主观评估通常反映了肝铁含量的生化测量值（通过电感耦合等离子体法测量）以及定量组织化学测量值（使用图像分析软件包和用 Perl 的普鲁士蓝染色的切片）。老年驴肝脏铁的积累与其他病理变化没有直接关系，可能是偶然发现。
