电刺激后兔门静脉释放的前列腺素的神经元起源。
The neuronal origin of prostaglandin released from the rabbit portal vein in response to electrical stimulation.
作者信息
Greenberg R
出版信息
Br J Pharmacol. 1978 May;63(1):79-85. doi: 10.1111/j.1476-5381.1978.tb07777.x.
Transmural electrical stimulation of the isolated portal vein of the rabbit was accompanied by the release of a prostaglandin-like substance (PLS). Thin layer chromatography coupled with bioassay indicated that this substance was probably prostaglandin E2 (PGE2). 2 Indomethacin potentiated the response of the portal vein to electrical stimulation at 2 Hz and abolished the release of the PLS. 3 There was no significant change in the amount of PLS released from the portal vein in response to electrical stimulation at 2 Hz when the contractile response of the portal vein was prevented by pretreatment with phentolamine or guanthidine. 4 In vitro denervation of the portal vein with 6-hydroxydopamine or the omission of Ca2+ from the bathing solution caused a significant reduction in the amount of PLS released from the portal vein in response to electrical stimulation at 2 hertz. 5 It is concluded that electrical stimulation of the isolated portal vein of the rabbit is accompanied by the release of a PLS, probably PGE2, from a neuronal source. The synthesis and release of the PLS is Ca2+ -dependent.
对兔离体门静脉进行透壁电刺激时，会伴随一种类前列腺素物质（PLS）的释放。薄层色谱结合生物测定表明，该物质可能是前列腺素E2（PGE2）。2 吲哚美辛增强了门静脉对2 Hz电刺激的反应，并消除了PLS的释放。3 当用酚妥拉明或胍乙啶预处理阻止门静脉的收缩反应时，门静脉对2 Hz电刺激释放的PLS量没有显著变化。4 用6-羟基多巴胺对门静脉进行体外去神经支配或从浴液中去除Ca2+，会导致门静脉对2赫兹电刺激释放的PLS量显著减少。5 得出的结论是，对兔离体门静脉进行电刺激时，会伴随从神经源释放一种PLS，可能是PGE2。PLS的合成和释放依赖于Ca2+。
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