Holécyová A, Török J
Ustavu normálnej a patologickej fyziológie SAV v Bratislave.
Bratisl Lek Listy. 1990 Nov;91(11):839-43.
Influence of cadmium on contractions of isolated v.portae of a rabbit, elicited by transmural nerve stimulation and by exogene norepinephrine, has been studied. Low concentrations of cadmium (10(-6) mol/l) potentiated contractions of the vessels in response to transmural nerve stimulation but they did not influence the magnitude of response to norepinephrine. Higher concentrations of cadmium (10(-5) - 10(-4) mol/l) inhibited contractions of v.portae elicited by both adrenergic stimuli. The results indicate that the effect of cadmium on contractions induced by transmural nerve stimulation is realized predominantly pre-synaptically, probably by influence on homeostasis of calcium in the nerve ending. Potentiation of responses of v.portae indicates a mechanism by which ions of cadmium could contribute to the development of hypertension.
研究了镉对家兔离体门静脉由跨壁神经刺激和外源性去甲肾上腺素引起的收缩的影响。低浓度镉（10⁻⁶摩尔/升）增强了血管对跨壁神经刺激的收缩反应，但不影响对去甲肾上腺素的反应幅度。较高浓度的镉（10⁻⁵ - 10⁻⁴摩尔/升）抑制了两种肾上腺素能刺激引起的门静脉收缩。结果表明，镉对跨壁神经刺激诱导的收缩的作用主要在突触前实现，可能是通过影响神经末梢中钙的稳态。门静脉反应的增强表明镉离子可能促成高血压发展的一种机制。
