Section of Rheumatology, Department of Medicine, LSU Health Sciences Center at New Orleans, 1542 Tulane Avenue, New Orleans, LA 70112-2822, USA.
Curr Rheumatol Rep. 2010 Oct;12(5):311-7. doi: 10.1007/s11926-010-0115-0.
The spondyloarthropathies comprise a large clinical spectrum of disorders that include well-defined clinical disorders such as ankylosing spondylitis and less well-defined disorders such as undifferentiated spondyloarthritis, which refers to patients with inflammatory back pain not fulfilling classification criteria for ankylosing spondylitis and without radiologic evidence of sacroillitis. These disorders share clinical and genetic features and are linked by their association with HLA-B27 and by the presence of enthesitis as the basic pathologic lesion. The prevalence of the entire group ranges between 0.6% and 1.9%. This article reviews the recent advances in our understanding of the clinical spectrum, pathogenesis, genetics, and management of undifferentiated spondyloarthritis.
脊柱关节炎包括一大类临床疾病，包括明确的临床疾病，如强直性脊柱炎，以及不太明确的疾病，如未分化脊柱关节炎，它是指有炎症性背痛但不符合强直性脊柱炎分类标准且无骶髂关节炎放射学证据的患者。这些疾病具有临床和遗传特征，通过与 HLA-B27 的关联以及附着点炎这一基本病理损伤而相互联系。整个疾病群体的患病率在 0.6%至 1.9%之间。本文综述了对未分化脊柱关节炎的临床表现、发病机制、遗传学和治疗的最新认识。
