Engle Keary M, Wang Dong-Hui, Yu Jin-Quan
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Angew Chem Int Ed Engl. 2010 Aug 16;49(35):6169-73. doi: 10.1002/anie.201002077.
Complementary catalytic systems have been developed in which the reactivity/selectivity balance in Pd(II)-catalyzed -C–H olefination can be modulated through ligand control. This allows for sequential C–H functionalization for the rapid preparation of 1,2,3-trisubstituted arenes. Additionally, a rare example of iterative C–H activation, in which a newly installed functional group directs subsequent C–H activation has been demonstrated.