健康受试者和II型家族性高脂蛋白血症患者血小板中低密度脂蛋白及激动剂诱导的钙离子动员
LDL- and agonist-induced Ca(2+)-mobilization in platelets of healthy subjects and in patients with familial hyperlipoproteinemia type II.
作者信息
Bochkov V N, Rozhkova T A, Lyakishev A A, Bochkova N A, Kukharchuk V V, Tkachuk V A
机构信息
Cardiology Research Center of the USSR, Moscow.
出版信息
Thromb Res. 1991 Feb 15;61(4):403-9. doi: 10.1016/0049-3848(91)90654-f.
PMID:2063348
Abstract
LDL induced a reversible increase in [Ca2+]i in platelets of healthy subjects and FH-patients. In both groups the effects of LDL were potentiated 2.3-fold by epinephrine. [Ca2+]i increases, induced by LDL, ADP and PAF were more prominent in platelets of FH-patients. This may explain the platelet hyperaggregability in such conditions.
摘要
低密度脂蛋白（LDL）可使健康受试者和家族性高胆固醇血症（FH）患者血小板内的钙离子浓度（[Ca2+]i）出现可逆性升高。在两组中，肾上腺素可使LDL的作用增强2.3倍。由LDL、二磷酸腺苷（ADP）和血小板活化因子（PAF）诱导的[Ca2+]i升高在FH患者的血小板中更为显著。这可能解释了在这种情况下血小板的高聚集性。
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