Archie's Cochlear Implant Laboratory, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Otol Neurotol. 2010 Oct;31(8):1293-9. doi: 10.1097/MAO.0b013e3181e8f965.
Children using bilateral cochlear implants (CIs) develop normal patterns of cortical activity when interimplant delays are minimized.
It is not clear whether bilateral CIs can promote normally functioning bilateral auditory pathways in children.
Cortical responses were recorded from 64 cephalic sites in 2 normal hearing participants and 8 children with 3 to 4 years of bilateral CI experience (age at first CI, 0.9-4.1 yr; age at second CI, 1.1-9.7 yr; interimplant delay, 0-5.8 yr).
Beamformer analyses on the dominant positive peak in CI users and P1 in normal hearers revealed that stimuli delivered from the left side evoked responses lateralized to right auditory cortex in the 2 participants with normal hearing and the 3 children receiving bilateral CIs with minimal interimplant delay at young ages. These 5 participants showed a shift in cortical lateralization away from the right cortical hemisphere when stimuli were moved to the right. In contrast, 4 of 5 children receiving bilateral CIs after longer delays and at older ages showed abnormal ipsilateral parietal activity in response to left stimuli and lateralization to the left cortical hemisphere in response to both right and left stimuli. The fifth child in this group showed abnormal lateralization to the ipsilateral cortex in response to both right and left stimuli.
The data suggest that, after 3 to 4 years of bilateral CI use, normal-like patterns of bilateral cortical activity are promoted in children receiving bilateral CI with minimal interimplant delays and young ages but are not present in older children who had longer interimplant delays.
当最小化植入体间延迟时，使用双侧人工耳蜗植入物 (CIs) 的儿童会发展出正常的皮质活动模式。
目前尚不清楚双侧 CIs 是否能促进儿童双侧听觉通路的正常功能。
从 2 名正常听力参与者和 8 名双侧 CI 经验 3 至 4 年的儿童（初次 CI 年龄为 0.9-4.1 岁；第二次 CI 年龄为 1.1-9.7 岁；植入体间延迟为 0-5.8 岁）的 64 个头颅部位记录皮质反应。
在 CI 用户的主导正峰和正常听力者的 P1 上进行的波束形成器分析表明，从左侧发出的刺激在 2 名正常听力者和 3 名接受双侧 CIs 的儿童中引起了对右听觉皮层的反应，这些儿童在年幼时接受双侧 CIs，植入体间延迟最小。这 5 名参与者在将刺激移至右侧时，皮质侧化从右半球向右侧转移。相比之下，4 名在较长延迟和较大年龄时接受双侧 CIs 的儿童在对左侧刺激时出现异常的同侧顶叶活动，并对右侧和左侧刺激均表现出向左侧皮质的侧化。该组中的第 5 名儿童在对右侧和左侧刺激时均表现出异常的同侧皮质侧化。
这些数据表明，在接受双侧 CIs 且植入体间延迟较小和年龄较小的儿童中，双侧 CI 使用 3 至 4 年后，会促进类似于正常的双侧皮质活动模式，但在植入体间延迟较长和年龄较大的儿童中则不存在。
