Timokhov V S, Kazakov I V, Azizov Iu M, Ipat'eva E I
Urol Nefrol (Mosk). 1991 Mar-Apr(2):13-6.
Acute renal failure was treated by intermittent hemofiltration in 19 patients (8 males and 11 females), 13 of which survived and 6 died. All of them underwent examinations for kinetics and clearance of middle-mass oligopeptides (MMOP) performed by gel filtration (sephadex G-15) and densitometry in UV light (280 nm) using C phi-24 device. Plasma levels of oligopeptides in acute renal failure were found increased 20-fold. They consisted mainly of MMOP (1000-3000 D) entering the 13th eluate fraction. There appeared a correlation between oligopeptides and creatinine plasma levels. Under hemofiltration lasting for 6.45 hours and replacing approximately total body fluid, nearly all the baseline extracellular oligopeptide pool was removed. The average rate of the filtration reached 127 ml/min, clearance of oligopeptides being 57.9 ml/min or more than 22 1 of fluid per one procedure. Intermittent hemofiltration went in enhanced (8-fold) MMOP generation responsible for residual high levels of them in plasma after the procedure.
对19例急性肾衰竭患者（8例男性，11例女性）进行了间歇性血液滤过治疗，其中13例存活，6例死亡。所有患者均采用凝胶过滤法（葡聚糖凝胶G - 15）及使用C phi - 24设备在紫外线（280nm）下进行光密度测定，对中分子寡肽（MMOP）的动力学和清除情况进行了检测。发现急性肾衰竭患者血浆中寡肽水平升高了20倍。它们主要由进入第13个洗脱组分的MMOP（1000 - 3000 D）组成。寡肽与血浆肌酐水平之间存在相关性。在持续6.45小时且置换量约为全身液体量的血液滤过过程中，几乎所有的基础细胞外寡肽池都被清除。滤过平均速率达到127 ml/min，寡肽清除率为57.9 ml/min或每次治疗超过22升液体。间歇性血液滤过导致MMOP生成增加（8倍），这是导致治疗后血浆中MMOP残留高水平的原因。
