Thurston J R, Rimler R B, Ackermann M R, Cheville N F, Sacks J M
United States Department of Agriculture, Agricultural Research Service, Ames, IA 50010.
Vet Microbiol. 1991 Apr;27(2):169-74. doi: 10.1016/0378-1135(91)90008-4.
Rats were vaccinated with a toxoid (D-toxoid) prepared from purified heat-labile toxin (D-toxin) produced by Pasteurella multocida serogroup D. Vaccination of rats with D-toxoid prevented death and other effects of D-toxin (hepatic necrosis, development of elevated leukocyte counts, lymphopenia, neutrophilia, and elevated complement titers) that occurred in phosphate buffered saline (PBS)-vaccinated control rats.
用由多杀巴斯德氏菌D血清群产生的纯化不耐热毒素(D毒素)制备的类毒素(D类毒素)对大鼠进行免疫接种。用D类毒素对大鼠进行免疫接种可预防D毒素(肝坏死、白细胞计数升高、淋巴细胞减少、中性粒细胞增多和补体滴度升高)在磷酸盐缓冲盐水(PBS)免疫接种的对照大鼠中所产生的死亡及其他影响。