类毒素诱导的抗体对多杀巴斯德菌皮肤坏死毒素攻击的大鼠的保护作用。

Protection of Pasteurella multocida dermonecrotic toxin-challenged rats by toxoid-induced antibody.

作者信息

Pettit R K, Rimler R B, Ackermann M R

机构信息

U.S. Department of Agriculture, National Animal Disease Center, Avian Diseases Research Unit, Ames, IA.

出版信息

Vet Microbiol. 1993 Feb;34(2):167-73. doi: 10.1016/0378-1135(93)90170-c.

DOI:10.1016/0378-1135(93)90170-c

PMID:8451832

Abstract

Two different doses of glutaraldehyde-treated Pasteurella multocida dermonecrotic toxin (PMDT) were used to immunize rats. Rats developed serum IgG antibodies specific for native PMDT, and IgG titers increased with dose and number of toxoid immunizations. Survival rates in both active immunization and passive serum neutralization experiments were dependent on dose of toxoid vaccination and serum levels of anti-PMDT IgG. Vaccination with toxoid prevented weight loss but not leukocytosis and increased complement titers in toxin-challenged rats. Toxoid, itself, induced minimal leukocytosis but no alterations in complement titers or weight gain.

摘要

使用两种不同剂量的戊二醛处理的多杀性巴氏杆菌皮肤坏死毒素（PMDT）对大鼠进行免疫。大鼠产生了针对天然PMDT的血清IgG抗体，并且IgG滴度随着类毒素免疫的剂量和次数而增加。主动免疫和被动血清中和实验中的存活率均取决于类毒素疫苗接种剂量和抗PMDT IgG的血清水平。用类毒素疫苗接种可防止体重减轻，但不能防止白细胞增多，并且可提高毒素攻击大鼠的补体滴度。类毒素本身仅诱导了轻微的白细胞增多，但对补体滴度或体重增加没有影响。