Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS-National Cancer Institute, Aviano (PN), Italy.
Int Rev Immunol. 2010 Aug;29(4):371-402. doi: 10.3109/08830185.2010.489658.
Our knowledge on the physiological role of CD4(+) T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD4(+) T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pathogenic infections and in mediating antitumor immune responses. On these bases, several immunotherapeutic approaches exploiting the cytotoxic properties of CD4(+) T cells are under investigation. This review summarizes available data supporting the functional and therapeutic relevance of cytotoxic CD4(+) T cells, with a particular focus on Epstein-Barr virus (EBV)-related disorders.
在过去的十年中，我们对 CD4(+) T 淋巴细胞的生理作用有了更多的了解：现有数据令人信服地表明，除了“辅助”作用外，CD4(+) T 细胞还可能具有溶解特性。这些效应细胞的细胞毒性功能在控制致病感染和介导抗肿瘤免疫反应方面具有重要作用。基于这些基础，正在研究几种利用 CD4(+) T 细胞细胞毒性特性的免疫治疗方法。本综述总结了支持细胞毒性 CD4(+) T 细胞功能和治疗相关性的现有数据，特别关注了 Epstein-Barr 病毒 (EBV) 相关疾病。
