MUC1免疫疗法。

MUC1 immunotherapy.

作者信息

Beatson Richard E, Taylor-Papadimitriou Joyce, Burchell Joy M

机构信息

Breast Cancer Biology Group, King's College London, Guy's Hospital, London SE1 9RT, UK.

出版信息

Immunotherapy. 2010 May;2(3):305-27. doi: 10.2217/imt.10.17.

DOI:10.2217/imt.10.17

PMID:20635898

Abstract

The overexpression and aberrant glycosylation of MUC1 is associated with a wide variety of cancers, making it an ideal target for immunotherapeutic strategies. This review highlights the main avenues of research in this field, focusing on adenocarcinomas, from the preclinical to clinical; the problems and possible solutions associated with each approach; and speculates on the direction of MUC1 immunotherapeutic research over the next 5-10 years.

摘要

MUC1的过表达和异常糖基化与多种癌症相关，使其成为免疫治疗策略的理想靶点。本综述重点介绍了该领域的主要研究途径，聚焦于从临床前到临床阶段的腺癌研究；每种方法相关的问题及可能的解决方案；并对未来5至10年MUC1免疫治疗研究的方向进行了推测。