Regenthal R, Voigt H, Reuter W, Preiss R
Institut für Klinische Pharmakologie, des Bereiches Medizin, Universität Leipzig.
Z Gesamte Inn Med. 1991 Apr;46(6):185-90.
20 male patients from 44 to 61 years of age with arteriosclerotic disturbances of the blood supply of the legs (stage II after Fontaine) were in the cross-over treated with 3 x 200 mg trapidil or 3 x 200 mg pentoxifylline daily. The duration of the therapy was in each case 6 weeks with a one-week elutriation phase. Statistically ascertained was an increase of the distance of intermittent claudication for the two drugs in patients with initial values lower than 550 m. On the other hand the tibio-brachial Doppler quotient and the submaximal blood supply established by the venous-occlusion plethysmography did not change. The post-ischaemic recovery phase of the transcutaneous oxygen partial pressure at the lower leg shortened in particular under the influence of trapidil. Lipid parameter, haematocrit, fibrinogen and plasma viscosity remained unchanged. The subjective tolerance of the two remedies was good.
20名年龄在44至61岁之间、患有腿部动脉硬化性供血障碍（Fontaine分期II期）的男性患者，接受了交叉治疗，分别每日服用3次200毫克曲匹地尔或3次200毫克己酮可可碱。每种治疗的持续时间均为6周，并伴有1周的洗脱期。经统计学确定，对于初始值低于550米的患者，两种药物均可使间歇性跛行距离增加。另一方面，胫臂多普勒指数以及通过静脉阻塞体积描记法测定的次最大供血量并未改变。特别是在曲匹地尔的影响下，小腿经皮氧分压的缺血后恢复阶段缩短。血脂参数、血细胞比容、纤维蛋白原和血浆粘度均保持不变。两种药物的主观耐受性良好。
