Endocrinology and Female Infertility Department, Reproductive Medicine Research Centre, Royan Institute, ACECR, Tehran, Iran.
Gynecol Endocrinol. 2011 Feb;27(2):117-20. doi: 10.3109/09513590.2010.501872. Epub 2010 Jul 19.
This study is designed to compare the results of in vitro fertilisation (IVF) in polycystic ovary syndrome (PCOS) and tubal factor disorders.
This was a cohort study performed in Royan Institute from 2007 to 2009. For this evaluation, 183 patients with PCOS and 183 patients with tubal factor (control group), whose ages ranged from 22 to 35 years underwent the long protocol of pituitary suppression and were included in the study.
In a defined time cycle, the number of ampoules used was higher for the control group (24.6 ± 0.9 versus 33.4 ± 0.9; p<0.0001). The PCOS group produced more oocytes (9.6 ± 0.5 versus 6.4 ± 0.3; p ≤ 0.0001) and embryos (3.7 ± 0.2 versus 2.7 ± 0.1; p=0.001). There were no significant differences in cancellation rate, the occurrence of ovarian hyperstimulation syndrome (OHSS) and cycles that resulted in lacked efficient follicle in the PCOS group and control group. Comparisons for biochemical pregnancy, implantation, clinical pregnancy and ongoing pregnancy rates showed no statistical difference. No significant differences were detected in miscarriage rates and complications.
The outcome of IVF in patients with PCOS and in patients with tubal infertility is similar.
本研究旨在比较多囊卵巢综合征（PCOS）和输卵管因素不孕患者体外受精（IVF）的结果。
这是 2007 年至 2009 年在罗扬研究所进行的一项队列研究。在这项评估中，年龄在 22 至 35 岁之间的 183 名 PCOS 患者和 183 名输卵管因素（对照组）患者接受了垂体抑制的长方案，并被纳入研究。
在规定的时间周期内，对照组使用的安瓿数更高（24.6 ± 0.9 对 33.4 ± 0.9；p<0.0001）。PCOS 组产生的卵母细胞（9.6 ± 0.5 对 6.4 ± 0.3；p ≤ 0.0001）和胚胎（3.7 ± 0.2 对 2.7 ± 0.1；p=0.001）更多。在取消率、卵巢过度刺激综合征（OHSS）的发生以及导致缺乏有效卵泡的周期方面，PCOS 组和对照组之间没有显著差异。生化妊娠、着床、临床妊娠和持续妊娠率的比较没有统计学差异。流产率和并发症没有显著差异。
PCOS 患者和输卵管性不孕患者的 IVF 结局相似。
