Cicinelli Ettore, Tinelli Raffaele, Lepera Achiropita, Pinto Vincenzo, Fucci Mariarosa, Resta Leonardo
4th Department of Obstetrics and Gynecology, Faculty of Medicine, University of Bari, Bari, Italy.
Acta Obstet Gynecol Scand. 2010 Aug;89(8):1061-5. doi: 10.3109/00016349.2010.498496.
To estimate if findings in women with chronic endometritis (CE) at fluid hysteroscopy correlate with the severity of inflammation at histology and to assess the possibility to score the severity of inflammation by fluid hysteroscopy.
Controlled clinical study.
University hospital.
A total of 211 outpatient women with a hysteroscopic diagnosis of CE and 30 control women without any such signs.
All patients underwent endometrial biopsy by means of a 3-mm Novak's curette connected to a 20-ml syringe without any anesthesia.
Hysteroscopic records were reviewed and compared with histologic findings by using an arbitrary inflammation score (Grades 0-2, no inflammation to severe infiltration, nodules and glands disruption, respectively).
A significant correlation between focal hyperemia and isolated micropolyps with Grade 1 inflammation and between generalized hyperemia, presence of diffuse micropolyps and polypoid endometrium with Grade 2 inflammation was found. Hysteroscopic and histologic grading showed good agreement (kappa index = 0.62).
In women affected by CE the severity of histological alterations may be reliably evaluated by fluid hysteroscopy. This information may be clinically useful not only for giving a prognosis and as a basis for interpretation of patients' complaints, but also for monitoring treatment.
评估在液体宫腔镜检查中慢性子宫内膜炎（CE）女性的检查结果是否与组织学炎症严重程度相关，并评估通过液体宫腔镜检查对炎症严重程度进行评分的可能性。
对照临床研究。
大学医院。
共有211例门诊宫腔镜诊断为CE的女性和30例无此类体征的对照女性。
所有患者在未使用任何麻醉的情况下，通过连接20毫升注射器的3毫米诺瓦克刮匙进行子宫内膜活检。
回顾宫腔镜检查记录，并通过任意炎症评分（0 - 2级，分别为无炎症至严重浸润、结节和腺体破坏）与组织学检查结果进行比较。
发现局灶性充血和孤立性微息肉与1级炎症之间、全身性充血、弥漫性微息肉和息肉样子宫内膜与2级炎症之间存在显著相关性。宫腔镜检查和组织学分级显示出良好的一致性（kappa指数 = 0.62）。
对于患有CE的女性，液体宫腔镜检查可可靠地评估组织学改变的严重程度。该信息不仅在给出预后和解释患者主诉方面具有临床实用性，而且在监测治疗方面也具有临床实用性。
