Göretzlehner G
Klinik für Gynäkologie und Geburtshilfe, Ernst-Moritz-Arndt-Universität Greifswald.
Zentralbl Gynakol. 1991;113(7):403-10.
The pharmacokinetics of synthetic contraceptive steroids are dependent on several factors: e.g. body weight, ethnic factors, dosage of steroids, particle size, absorption, metabolism, elimination, affinity to proteins (SHBG, albumine), interaction etc. The dosage-dependent changes of pharmacokinetics progestagens and estrogens are presented. Besides, the principle of interactions between estrogens and progestagens and other drugs is discussed. Pharmacokinetic studies of oral contraceptive steroids should be designed according to the recommended modus of application. The analysis of the involved steroids, estrogen and progestagen, and of the combined pill should be carried out with regard to age, season and duration of application.
例如体重、种族因素、甾体激素剂量、颗粒大小、吸收、代谢、消除、与蛋白质（性激素结合球蛋白、白蛋白）的亲和力、相互作用等。文中介绍了孕激素和雌激素药代动力学的剂量依赖性变化。此外，还讨论了雌激素与孕激素及其他药物之间的相互作用原理。口服避孕甾体激素的药代动力学研究应根据推荐的应用方式进行设计。对所涉及的甾体激素、雌激素和孕激素以及复方避孕药的分析应考虑年龄、季节和用药时间。
