Okada H
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine.
Nihon Rinsho. 1994 Mar;52(3):617-23.
Synthetic steroids, having delta 4-3-ketone structure, are commonly metabolised to the corresponding tetrahydro-metabolites. The reduction of the 20-ketone group is also essential for pregnan series progestogens. When these metabolic pathways are obstructed in some way, steroids are hydroxylated at proper positions. Hydroxylation of a steroid is primarily directed to form the inactive form, namely, conjugated steroid. However, in some cases, it induces activation or activity change to the original compound. Activation of lynestrenol, as a progestogen and the conversion of norethindrone to ethynylestradiol, are examples. Metabolism of some new steroids and factors affecting the effect of oral contraceptive pills are discussed.
具有△4-3-酮结构的合成类固醇通常会代谢为相应的四氢代谢物。对于孕甾系列孕激素来说，20-酮基的还原也至关重要。当这些代谢途径以某种方式受阻时，类固醇会在适当位置发生羟基化。类固醇的羟基化主要是为了形成无活性形式，即结合类固醇。然而，在某些情况下，它会诱导原始化合物的活化或活性变化。炔雌醇作为孕激素的活化以及炔诺酮向炔雌醇的转化就是例子。本文讨论了一些新型类固醇的代谢以及影响口服避孕药效果的因素。
