[鼻同步间歇强制通气与经鼻持续气道正压通气治疗早产儿呼吸窘迫综合征的随机试验]
[Randomized trail of nasal synchronized intermittent mandatory ventilation compared with nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome].
作者信息
Gao Wei-Wei, Tan San-Zhi, Chen Yun-Bin, Zhang Yong, Wang Yue
机构信息
Guangdong Provincial Women and Children's Hospital, Guangzhou 510010, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2010 Jul;12(7):524-6.
OBJECTIVE
To compare the efficacy of nasal synchronized intermittent mandatory ventilation (nSIMV) and nasal continuous positive airway pressure (nCPAP) in preterm infants with respiratory distress syndrome (RDS).
METHODS
Fifty preterm infants with RDS who received pulmonary surfactant were randomized to nSIMV and nCPAP groups after extubation. Clinical signs, symptoms and blood gas results following nSIMV or nCPAP were compared in the two groups.
RESULTS
Compared with the nCPAP group, the nSIMV group had a lower incidence of failure respiratory support (24% vs 60%; P<0.05), a lower incidence of hypercarbonia (12% vs 40%; P<0.05) and a lower incidence of hypoxia (24% vs 36%; P<0.05).
CONCLUSIONS
nSIMV is more effective in respiratory support in preterm infants with RDS.
目的
比较经鼻同步间歇指令通气（nSIMV）与经鼻持续气道正压通气（nCPAP）对患有呼吸窘迫综合征（RDS）的早产儿的疗效。
方法
五十名接受肺表面活性物质治疗的RDS早产儿在拔管后被随机分为nSIMV组和nCPAP组。比较两组在接受nSIMV或nCPAP治疗后的临床体征、症状及血气结果。
结果
与nCPAP组相比，nSIMV组呼吸支持失败发生率较低（24% 对60%；P<0.05），高碳酸血症发生率较低（12% 对40%；P<0.05），低氧血症发生率较低（24% 对36%；P<0.05）。
结论
nSIMV对患有RDS的早产儿的呼吸支持更有效。
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