醋酸格拉替雷反应性T淋巴细胞在体外调节少突胶质前体细胞数量：胰岛素样生长因子-2的作用。
Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2.
作者信息
Zhang Y, Jalili F, Ouamara N, Zameer A, Cosentino G, Mayne M, Hayardeny L, Antel J P, Bar-Or A, John G R
机构信息
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.
出版信息
J Neuroimmunol. 2010 Oct 8;227(1-2):71-9. doi: 10.1016/j.jneuroim.2010.06.014. Epub 2010 Jul 15.
Glatiramer acetate (GA) is an immunomodulator approved for therapy of relapsing-remitting multiple sclerosis (RRMS), but recent findings indicate that it may also have additional, neurotrophic effects. Here, we found that supernatants from human GA-reactive T lymphocytes potentiated oligodendrocyte numbers in rodent and human oligodendrocyte progenitor (OPC) cultures. Effects of Th2-polarized lines were stronger than Th1-polarized cells. Microarray and ELISA analyses revealed that neurotrophic factors induced in Th2- and Th1-polarized GA-reactive lines included IGF-2 and BMP-7 respectively, and functional studies confirmed IGF-2 as trophic for OPCs. Our results support the concept that GA therapy may result in supportive effects on oligodendrocytes in RRMS patients.
醋酸格拉替雷（GA）是一种被批准用于复发缓解型多发性硬化症（RRMS）治疗的免疫调节剂，但最近的研究结果表明，它可能还具有额外的神经营养作用。在此，我们发现来自人GA反应性T淋巴细胞的上清液可增强啮齿动物和人少突胶质细胞祖细胞（OPC）培养物中少突胶质细胞的数量。Th2极化细胞系的作用强于Th1极化细胞。微阵列和酶联免疫吸附测定分析显示，Th2和Th1极化的GA反应性细胞系中诱导产生的神经营养因子分别为胰岛素样生长因子2（IGF-2）和骨形态发生蛋白7（BMP-7），功能研究证实IGF-2对OPC具有营养作用。我们的结果支持这样一种观点，即GA治疗可能对RRMS患者的少突胶质细胞产生支持作用。
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