NG2 胶质细胞在脑血管病中的作用。
Roles of NG2 Glia in Cerebral Small Vessel Disease.
机构信息
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
出版信息
Neurosci Bull. 2023 Mar;39(3):519-530. doi: 10.1007/s12264-022-00976-w. Epub 2022 Nov 18.
Cerebral small vessel disease (CSVD) is one of the most prevalent pathologic processes affecting 5% of people over 50 years of age and contributing to 45% of dementia cases. Increasing evidence has demonstrated the pathological roles of chronic hypoperfusion, impaired cerebral vascular reactivity, and leakage of the blood-brain barrier in CSVD. However, the pathogenesis of CSVD remains elusive thus far, and no radical treatment has been developed. NG2 glia, also known as oligodendrocyte precursor cells, are the fourth type of glial cell in addition to astrocytes, microglia, and oligodendrocytes in the mammalian central nervous system. Many novel functions for NG2 glia in physiological and pathological states have recently been revealed. In this review, we discuss the role of NG2 glia in CSVD and the underlying mechanisms.
脑小血管病 (CSVD) 是最常见的病理过程之一，影响 50 岁以上人群的 5%，并导致 45%的痴呆病例。越来越多的证据表明，慢性低灌注、脑血管反应性受损和血脑屏障渗漏在 CSVD 中起病理作用。然而，迄今为止，CSVD 的发病机制仍不清楚，也没有开发出根治性治疗方法。NG2 胶质细胞，也称为少突胶质细胞前体细胞，是哺乳动物中枢神经系统中除星形胶质细胞、小胶质细胞和少突胶质细胞之外的第四种胶质细胞。最近，人们发现了 NG2 胶质细胞在生理和病理状态下的许多新功能。在这篇综述中，我们讨论了 NG2 胶质细胞在 CSVD 中的作用及其潜在机制。
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