Hospital for Sick Children, Canada.
Neurology. 2013 Aug 27;81(9):850-2. doi: 10.1212/WNL.0b013e3182a2cc4a. Epub 2013 Jul 24.
Glatiramer acetate (GA), a synthetic copolymer, is a frequently used first-line treatment for relapsing-remitting multiple sclerosis (RRMS). Probable autoimmune hepatotoxicity during GA treatment has been reported,(1-4) but GA hepatotoxicity in the absence of positive autoimmune markers has not previously been described. Here, we report GA-induced hepatotoxicity in a pediatric patient with multiple sclerosis (MS).
醋酸格拉替雷(GA)是一种合成的共聚物,是治疗复发性缓解型多发性硬化症(RRMS)的常用一线药物。(1-4)有报道称 GA 治疗期间可能发生自身免疫性肝毒性,但以前没有描述过无阳性自身免疫标志物的 GA 肝毒性。在此,我们报告了一例多发性硬化症(MS)患儿的 GA 诱导性肝毒性。