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[血清因子缺乏对SV3T3转化成纤维细胞增殖的部分抑制作用的特性研究]

[Characterization of the partial inhibition, by deficiency in serum factors, of multiplication of SV3T3 transformed fibroblasts].

作者信息

Rampini C, Dubois C

出版信息

C R Acad Hebd Seances Acad Sci D. 1978 Jan;286(1):105-8.

PMID:206376
Abstract

Partial inhibition, by serum starvation, of multiplication of SV3T3 transformed fibroblasts was studied by cultivating cells in a medium containing 1% of serum. Two different and successive states are described: a first step, with a rate of multiplication for 24 hrs, which is lowered (2 instead of 3 in a normal medium containing 10% of serum) but which remains constant (i.e. exponential multiplication), the observed inhibition being reversed by normal medium; a second step, where the rate of multiplication for 24 hrs, decreases very fast, and which is not reversible.

摘要

通过在含有1%血清的培养基中培养细胞,研究了血清饥饿对SV3T3转化成纤维细胞增殖的部分抑制作用。描述了两种不同且连续的状态:第一步,24小时的增殖速率降低(在含有10%血清的正常培养基中为3,此处为2),但保持恒定(即指数增殖),观察到的抑制作用可被正常培养基逆转;第二步,24小时的增殖速率迅速下降,且不可逆。

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