Beclin 1 与 survivin 的相互作用调节人神经胶质瘤细胞对 TRAIL 诱导凋亡的敏感性。
Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis.
机构信息
Department of Pharmacology and The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
出版信息
FEBS Lett. 2010 Aug 20;584(16):3519-24. doi: 10.1016/j.febslet.2010.07.018. Epub 2010 Jul 16.
Abstract
We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.
摘要
我们报道了自噬关键调节因子 Beclin 1 与凋亡抑制蛋白家族成员 survivin 之间的一种新的相互作用。我们发现，Beclin 1 的敲低降低了 survivin 蛋白的表达，并且当 Beclin 1 表达被沉默时 survivin 的周转率增加。Beclin 1 的敲低使神经胶质瘤细胞对 TRAIL 诱导的凋亡敏感，而 survivin 的引入拮抗了这种敏化作用，表明 survivin 的下调介导了对 TRAIL 诱导的凋亡的增强敏感性。这些结果表明 Beclin 1 和 survivin 之间存在新的相互作用，并且可能为自噬和凋亡之间的串扰提供潜在的机制。
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本文引用的文献
1
Endogenous tumor suppression mediated by PTEN involves survivin gene silencing.
Cancer Res. 2009 Jun 15;69(12):4954-8. doi: 10.1158/0008-5472.CAN-09-0584. Epub 2009 May 26.
2
Beclin 1: a BH3-only protein that fails to induce apoptosis.
Oncogene. 2009 May 28;28(21):2125-7. doi: 10.1038/onc.2009.83. Epub 2009 Apr 27.
3
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Int J Oncol. 2009 Mar;34(3):729-42. doi: 10.3892/ijo_00000199.
4
The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin.
Mol Cancer Ther. 2008 Nov;7(11):3566-74. doi: 10.1158/1535-7163.MCT-08-0236.
5
IAP-targeted therapies for cancer.
Oncogene. 2008 Oct 20;27(48):6252-75. doi: 10.1038/onc.2008.302.
6
Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells.
J Biol Chem. 2008 Jul 11;283(28):19665-77. doi: 10.1074/jbc.M710169200. Epub 2008 Mar 28.
7
Silencing Livin gene expression to inhibit proliferation and enhance chemosensitivity in tumor cells.
Cancer Gene Ther. 2008 Jun;15(6):402-12. doi: 10.1038/cgt.2008.16. Epub 2008 Mar 14.
8
Survivin, cancer networks and pathway-directed drug discovery.
Nat Rev Cancer. 2008 Jan;8(1):61-70. doi: 10.1038/nrc2293.
9
Differential interactions between Beclin 1 and Bcl-2 family members.
Autophagy. 2007 Nov-Dec;3(6):561-8. doi: 10.4161/auto.4713. Epub 2007 Jul 8.
10
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.
Nat Cell Biol. 2006 Jul;8(7):688-99. doi: 10.1038/ncb1426. Epub 2006 Jun 25.
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