Department of Biochemistry, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK
The Wistar Institute Cancer Center, Philadelphia, PA 19104, USA.
J Cell Sci. 2019 Apr 4;132(7):jcs223826. doi: 10.1242/jcs.223826.
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. In this Cell Science at a Glance article and accompanying poster, we summarise our knowledge of survivin 21 years on from its initial discovery. We describe the structure, expression and function of survivin, highlight its interactome and conclude by describing anti-survivin strategies being trialled.
存活素（也称为 BIRC5）是一种进化上保守的真核蛋白，对细胞分裂至关重要，并能抑制细胞死亡。通常情况下，它仅在活跃增殖的细胞中表达，但在大多数（如果不是全部）癌症中都上调；因此，它作为一种潜在的肿瘤治疗靶点受到了广泛关注。在这篇《细胞科学一瞥》文章及其配套海报中，我们总结了存活素自最初发现以来 21 年的研究进展。我们描述了存活素的结构、表达和功能，突出了其相互作用组，并在最后描述了正在试验的抗存活素策略。
