School of Chemistry and Chemical Engineering, Henan University of, Technology, LianHua Road, Zhengzhou 450051, China.
Anal Chim Acta. 2010 Jul 26;674(1):53-8. doi: 10.1016/j.aca.2010.06.018. Epub 2010 Jun 25.
A novel molecularly imprinted polymer (MIP) that was applied to a solid-phase micro-extraction (SPME) device, which could be coupled directly to gas chromatograph and mass spectrometer (GC/MS), was prepared using dibutyl phthalate (DBP) as the template molecule. The characteristics and application of this fiber were investigated. Electron microscope images indicated that the MIP-coated solid-phase micro-extraction (MI-SPME) fibers were homogeneous and porous. The extraction yield of DBP with the MI-SPME fibers was higher than that of the non-imprinted polymer (NIP)-coated SPME (NI-SPME) fibers. The MI-SPME fibers had a higher selectivity to other phthalates that had similar structures as DBP. A method was developed for the determination of phthalates using MI-SPME fibers coupled with GC/MS. The extraction conditions were optimized. Detection limits for the phthalate samples were within the range of 2.17-20.84 ng L(-1). The method was applied to five kinds of phthalates dissolved in spiked aqueous samples and resulted in recoveries of up to 94.54-105.34%, respectively. Thus, the MI-SPME fibers are suitable for the extraction of trace phthalates in complicated samples.
一种新型的分子印迹聚合物（MIP）被应用于固相微萃取（SPME）装置，该装置可直接与气相色谱和质谱联用（GC/MS），以邻苯二甲酸二丁酯（DBP）为模板分子进行制备。研究了这种纤维的特性和应用。电子显微镜图像表明，MIP 涂层固相微萃取（MI-SPME）纤维是均匀且多孔的。MI-SPME 纤维对 DBP 的萃取产率高于非印迹聚合物（NIP）涂层的 SPME（NI-SPME）纤维。MI-SPME 纤维对具有与 DBP 相似结构的其他邻苯二甲酸酯具有更高的选择性。开发了一种使用 MI-SPME 纤维与 GC/MS 联用测定邻苯二甲酸盐的方法。优化了萃取条件。邻苯二甲酸盐样品的检测限在 2.17-20.84ng/L 范围内。该方法应用于五种溶解在加标水样中的邻苯二甲酸盐，回收率高达 94.54-105.34%。因此，MI-SPME 纤维适用于复杂样品中痕量邻苯二甲酸盐的提取。
