Shamshirsaz Alireza A, Benn Peter, Egan James F X
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-2947, USA.
Clin Lab Med. 2010 Sep;30(3):667-76. doi: 10.1016/j.cll.2010.04.013.
Considerable advances have been made in identifying women whose pregnancies are at the greatest risk for fetal Down syndrome and other aneuploidies. Maternal serum tests and ultrasonography in either the first or second trimester provide effective prenatal screening. However, the most efficacious protocols are based on the combination of first- and second-trimester tests. In this article the advantages and best strategies in providing these sequential screening protocols are discussed.
在识别怀孕胎儿患唐氏综合征和其他非整倍体风险最高的女性方面已经取得了相当大的进展。孕早期或孕中期的母体血清检测和超声检查可提供有效的产前筛查。然而，最有效的方案是基于孕早期和孕中期检测的联合。本文讨论了提供这些序贯筛查方案的优势和最佳策略。
