Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium.
Cell Host Microbe. 2010 Jul 22;8(1):44-54. doi: 10.1016/j.chom.2010.06.007.
Viral and microbial infections often elicit programmed cell death as part of the host defense system or as a component of the survival strategy of the pathogen. It is thus not surprising that pathogens have evolved an array of toxins and virulence factors to modulate host cell death pathways. Apoptosis, necrosis, and pyroptosis constitute the three major cell death modes for elimination of infected cells. Herein, we discuss the signaling pathways underlying the principal host cell death mechanisms and provide an overview of the strategies employed by viral and microbial pathogens to manipulate these cell death processes.
病毒和微生物感染常引发程序性细胞死亡，这是宿主防御系统的一部分，也是病原体生存策略的组成部分。因此，病原体进化出一系列毒素和毒力因子来调节宿主细胞死亡途径也就不足为奇了。细胞凋亡、坏死和细胞焦亡是清除感染细胞的三种主要细胞死亡模式。在此，我们讨论了主要宿主细胞死亡机制的信号通路，并概述了病毒和微生物病原体用来操纵这些细胞死亡过程的策略。
