Bauer Ricarda M, Gratzke Christian, Roosen Alexander, Hocaoglu Yasmin, Mayer Margit E, Buchner Alexander, Stief Christian G, May Florian
Department of Urology, Ludwig Maximilian University, Munich, Germany.
Urol Int. 2011;86(1):68-72. doi: 10.1159/000316080. Epub 2010 Jul 15.
The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB).
Botulinum toxin A injection was performed in 56 patients with idiopathic OAB. Patients were followed up for 6 months concerning side effects and patients' satisfaction.
Different types of side effects were assessed such as dry mouth (19.6%), arm weakness (8.9%), eyelid weakness (8.9%), leg weakness (7.1%), torso weakness (5.4%), impaired vision (5.4%) and dysphagia (5.4%). In all cases, symptoms were mild and transient. Urological complications such as gross hematuria (17.9%), acute urinary retention (8.9%) and acute urinary tract infection (7.1%) were noticed. In all cases, acute urinary retention was transient and treated with temporary intermittent self-catheterization. There was no statistically significant correlation between dosage and observed side effects. Patients' satisfaction rate was high (71.4%).
Intradetrusor injection of botulinum toxin was associated with a high rate of neurourological side effects. In general, side effects were transient, mild and did not require special treatment.
本研究旨在对肉毒杆菌毒素注射至逼尿肌治疗特发性膀胱过度活动症（OAB）的开放标签研究中患者报告的副作用进行前瞻性评估。
对56例特发性OAB患者进行了肉毒杆菌毒素A注射。就副作用和患者满意度对患者进行了6个月的随访。
评估了不同类型的副作用，如口干（19.6%）、手臂无力（8.9%）、眼睑无力（8.9%）、腿部无力（7.1%）、躯干无力（5.4%）、视力受损（5.4%）和吞咽困难（5.4%）。所有病例中，症状均为轻度且短暂。注意到了泌尿系统并发症，如肉眼血尿（17.9%）、急性尿潴留（8.9%）和急性尿路感染（7.1%）。所有病例中，急性尿潴留均为短暂性，通过临时间歇性自我导尿进行治疗。剂量与观察到的副作用之间无统计学显著相关性。患者满意度较高（71.4%）。
逼尿肌内注射肉毒杆菌毒素与较高的神经泌尿系统副作用发生率相关。总体而言，副作用是短暂、轻微的，不需要特殊治疗。
