Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), SV-IBI, Building AI, Station 15, Lausanne, Switzerland.
Cell Mol Life Sci. 2010 Oct;67(20):3407-23. doi: 10.1007/s00018-010-0454-z. Epub 2010 Jul 17.
The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic processes. Its properties as an energy sensor allow it to couple the energy status of the cell to the metabolic environment. These adaptations not only take place through the acute modulation of key metabolic enzymes via direct phosphorylation, but also through a slower transcriptional adaptative response. The question of how AMPK regulates the expression of a number of gene sets, such as those related to mitochondrial biogenesis, energy production and oxidative protection, is only beginning to be elucidated, and still many questions remain to be answered. In this review we will try to integrate our current knowledge on how AMPK regulates transcription in muscle and liver, which will serve as examples to illustrate the major advances in the field and the key challenges ahead.
腺苷酸活化蛋白激酶（AMPK）是分解代谢与合成代谢过程的关键调节剂。它作为能量传感器的特性使其能够将细胞的能量状态与代谢环境联系起来。这些适应性变化不仅通过直接磷酸化对关键代谢酶的急性调节发生，而且还通过较慢的转录适应性反应发生。AMPK 如何调节许多基因集的表达的问题，例如与线粒体生物发生、能量产生和氧化保护相关的基因集的表达，才刚刚开始被阐明，还有许多问题有待解答。在这篇综述中，我们将尝试整合我们目前关于 AMPK 如何调节肌肉和肝脏转录的知识，这将作为例证来说明该领域的主要进展和未来的关键挑战。
