Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China.
Breast Cancer Res Treat. 2011 Jan;125(2):571-4. doi: 10.1007/s10549-010-0993-x. Epub 2010 Jul 17.
Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) which located in the pre-miRNA may affect the processing and then influence the expression of mature miRNA. Previous studies yielded conflicting results as to the association of two common polymorphisms in pre-miRNAs (i.e. hsa-miR-146 rs2910164 and hsa-miR-196a2 rs11614913) with breast cancer. To derive a more precise effect on the association between these polymorphisms and breast cancer risk, we conducted a meta-analysis. Through retrieving PubMed for the period up to May 2010, a total of four studies were identified with 3,007 cases and 3,718 controls for has-miR-146a rs2910164 polymorphism and with 3,287 cases and 4,298 controls for hsa-miR-196a2 rs11614913 polymorphism. We found that individuals carrying CC genotype of has-miR-196a2 rs11614913 polymorphism was associated with an increased breast cancer risk in homozygote comparison (OR = 1.30; 95% CI, 1.01-1.68), and dominant model (OR = 1.11; 95% CI, 1.01-1.23). However, no significant association between has-miR-146a rs2910164 polymorphism and breast cancer risk was observed in all comparison models tested. These findings suggest that has-miR-196a2 rs11614913 polymorphism may play crucial roles in breast cancer development.
新出现的证据表明，miRNAs 作为肿瘤抑制因子或癌基因参与人类的致癌作用。位于前体 miRNA 中的单核苷酸多态性 (SNP) 可能会影响 miRNA 的加工，从而影响成熟 miRNA 的表达。先前的研究对于两个常见的前体 miRNA 多态性 (即 hsa-miR-146 rs2910164 和 hsa-miR-196a2 rs11614913) 与乳腺癌的相关性得出了相互矛盾的结果。为了更准确地评估这些多态性与乳腺癌风险之间的关联，我们进行了一项荟萃分析。通过检索截至 2010 年 5 月的 PubMed 数据库，共确定了 4 项研究，共有 3007 例病例和 3718 例对照用于 hsa-miR-146a rs2910164 多态性，共有 3287 例病例和 4298 例对照用于 hsa-miR-196a2 rs11614913 多态性。我们发现，hsa-miR-196a2 rs11614913 多态性的 CC 基因型个体在同型比较 (OR = 1.30; 95% CI, 1.01-1.68) 和显性模型 (OR = 1.11; 95% CI, 1.01-1.23) 中与乳腺癌风险增加相关。然而，在所有测试的比较模型中，hsa-miR-146a rs2910164 多态性与乳腺癌风险之间均未观察到显著相关性。这些发现表明，hsa-miR-196a2 rs11614913 多态性可能在乳腺癌的发生发展中发挥关键作用。
