Channing Laboratory, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
Cancer Causes Control. 2010 Nov;21(11):1817-28. doi: 10.1007/s10552-010-9609-3. Epub 2010 Jul 18.
To examine the mediating effect of childhood abuse on sexual orientation disparities in tobacco and alcohol use during adolescence.
We carried out analyses with data from over 62,000 women in the ongoing Nurses' Health Study II cohort who provided information on sexual orientation, childhood abuse occurring by age 11, and tobacco and alcohol use in adolescence. We used multivariate regression analyses, controlling for confounders, to estimate the mediating effect of childhood abuse on the association between sexual orientation and tobacco and alcohol use in adolescence.
Lesbian and bisexual orientation and childhood abuse were positively associated with greater risk of tobacco and alcohol use during adolescence. For lesbians, the estimated proportion of excess tobacco and alcohol use in adolescence relative to use among heterosexual women that was mediated by abuse in childhood ranged from 7 to 18%; for bisexual women, the estimated proportion of excess use mediated by abuse ranged from 6 to 13%.
Elevated childhood abuse in lesbian and bisexual women partially mediated excess tobacco and alcohol use in adolescence relative to heterosexual women. Interventions to prevent child abuse may reduce sexual orientation disparities in some of the leading causes of cancer in women.
探讨儿童期虐待在青少年时期吸烟和饮酒的性取向差异中的中介作用。
我们对正在进行的护士健康研究 II 队列中超过 62000 名女性的数据进行了分析，这些女性提供了关于性取向、11 岁前发生的儿童期虐待以及青少年时期吸烟和饮酒的信息。我们使用多变量回归分析，控制混杂因素，估计儿童期虐待对性取向与青少年时期吸烟和饮酒之间关联的中介作用。
女同性恋和双性恋取向以及儿童期虐待与青少年时期吸烟和饮酒的风险增加呈正相关。对于女同性恋者，与异性恋女性相比，儿童期虐待导致的青少年时期吸烟和饮酒过度的估计比例在 7%至 18%之间；对于双性恋女性，儿童期虐待导致的过度使用的估计比例在 6%至 13%之间。
在女同性恋和双性恋女性中，儿童期虐待的发生率升高部分解释了与异性恋女性相比，青少年时期吸烟和饮酒过度的情况。预防儿童虐待的干预措施可能会减少女性中一些主要癌症病因的性取向差异。
