Iglseder Bernhard, Dovjak Peter, Benvenuti-Falger Ursula, Böhmdorfer Birgit, Lechleitner Monika, Otto Ronald, Roller Regina E, Sommeregger Ulrike, Gosch Markus
Universitätsklinik für Geriatrie, Paracelsus Medizinische Privatuniversität, Salzburg, Austria.
Abteilung für Akutgeriatrie/Remobilisation, Landeskrankenhaus Gmunden, Gmunden, Austria.
Wien Med Wochenschr. 2010 Jun;160(11-12):281-285. doi: 10.1007/s10354-010-0787-0.
Drugs have been widely associated with the development of delirium in the elderly and represent the most common reversible cause of this condition. This is of importance since successful treatment depends on identifying the reversible contributing factors. Medications with anticholinergic properties, tranquilizers, analgesics and narcotics are common causes of drug-induced delirium. This article provides practical approach to prevent and recognise this condition, reviews the underlying neurotransmitter imbalances and reconsiders age-related changes of pharmacological effects, which may contribute to the development of delirium.
药物与老年人谵妄的发生密切相关,是这种情况最常见的可逆性病因。这一点很重要,因为成功的治疗取决于识别出可逆的促成因素。具有抗胆碱能特性的药物、镇静剂、镇痛药和麻醉药是药物性谵妄的常见病因。本文提供了预防和识别这种情况的实用方法,回顾了潜在的神经递质失衡,并重新审视了可能导致谵妄发生的与年龄相关的药理作用变化。