卡培他滨所致手足综合征的高发生率。

High frequency of hand foot syndrome with capecitabine.

作者信息

Kamil Muhammad, Haron Mubassir, Yosuff Narazah, Khalid Imran, Azman Nizuwan

机构信息

Department of Oncology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia.

出版信息

J Coll Physicians Surg Pak. 2010 Jun;20(6):421-2.

PMID:20642979

Abstract

A hospital based cross-sectional retrospective study was conducted to determine the frequency of hand foot syndrome (HFS) with Capecitabine as a single agent and in combination with Oxaliplatin. The study included 43 consecutive cases of colorectal carcinoma and conducted from June till December 2008. Patients on palliative care were excluded. SPSS was used for the application of chi-square test, by keeping the level of significance as p < 0.05. Fifteen (34.9%) patients developed HFS, 10 in the single-agent and 5 in the combination group. No significant association of HFS with either regimens was noted (p=0.876).

摘要

开展了一项基于医院的横断面回顾性研究，以确定卡培他滨单药治疗及与奥沙利铂联合治疗时手足综合征（HFS）的发生率。该研究纳入了43例连续性结直肠癌病例，研究时间为2008年6月至12月。排除接受姑息治疗的患者。使用SPSS进行卡方检验，显著性水平设定为p < 0.05。15例（34.9%）患者发生了HFS，单药治疗组有10例，联合治疗组有5例。未发现HFS与任何一种治疗方案有显著相关性（p = 0.876）。