Expert Opin Drug Saf. 2011 Mar;10(2):159-69. doi: 10.1517/14740338.2011.546342. Epub 2010 Dec 22.
Hand-foot syndrome (HFS), or palmar-plantar erythrodysesthesia, is a common side effect in patients taking long-term 5-fluorouracil treatment and is the most frequently reported side effect of oral capecitabine therapy (≥ 50% of patients). Although the pathogenesis of HFS is not fully understood, it may be due to damaged deep capillaries in the soles of the feet and palms of the hands, leading to a COX inflammatory-type reaction, or related to enzymes involved in the metabolism of capecitabine, namely, thymidine phosphorylase and dihydropyrimidine dehydrogenase. Ethnic variations in the clinical manifestation of HFS warrant further attention, and an alternative system for grading HFS in non-white patients has been proposed. In addition to treatment interruption and dose reduction, supportive treatments can help alleviate symptoms. Because capecitabine is an oral therapy administered at home, it is crucial that patients understand the importance of complying with treatment, be aware of the possibility of HFS, and inform the doctor or nurse immediately if symptoms of HFS develop. Several cases of HFS are presented.
手足综合征（HFS），又称掌跖红斑感觉迟钝，是长期接受氟尿嘧啶治疗的患者常见的副作用，也是卡培他滨口服治疗中最常报告的副作用（≥50%的患者）。虽然 HFS 的发病机制尚未完全阐明，但它可能是由于足底和手掌深部毛细血管受损，导致 COX 炎症反应型，或与卡培他滨代谢相关的酶有关，即胸苷磷酸化酶和二氢嘧啶脱氢酶。HFS 的临床表现存在种族差异，需要进一步关注，并且已经提出了一种用于非白人患者的 HFS 分级替代系统。除了中断治疗和减少剂量外，支持性治疗可以帮助缓解症状。由于卡培他滨是一种在家中进行的口服治疗药物，因此患者了解遵守治疗方案的重要性、意识到发生 HFS 的可能性，并在出现 HFS 症状时立即告知医生或护士，这一点至关重要。本文呈现了几个 HFS 的病例。
