Imai S, Nio Y, Shiraishi T, Manabe T, Tobe T
First Department of Surgery, Kyoto University Faculty of Medicine, Japan.
Anticancer Res. 1991 Mar-Apr;11(2):657-64.
Pancreatic cancer is one of the neoplasms resistant to chemotherapy. In the present study human pancreatic cancer xenografts (3 adenocarcinomas and 1 cystoadenocarcinoma) were subcutaneously transplanted in nude mice and after the tumors grew to 100-300 mm3, the mice were intraperitoneally administered with mitomycin C (MMC), adriamycin (ADR), 5-fluorouracil (5-FU), carboquone (CQ), cisplatinum (CDDP), nimustine chloride (ACNU) or DWA2114R at 1/3 LD50 on days 0.4, and 8. The tumor sizes on day 12 were compared with those on day 0. MMC and CQ significantly inhibited the tumor growth of 3 lines, and ACNU, CDDP and ADR inhibited the growth of 1 line. Further, 5-FU, futrafur, carmofur, UFT and L-phenylalanine mustard (L-PAM) were orally administered to mice into which 1 adenocarcinoma line had been transplanted. While none of fluoropyrimidines inhibited tumor growth, L-PAM at 4 mg/kg significantly inhibited growth, although it was accompanied by severe body weight loss. In the present study several agents significantly inhibited tumor growth, but none of them could induce the regression of the tumor when used singly. These results suggest that CQ, ACNU, CDDP and L-PAM may be applied to the chemotherapy of pancreatic cancer. However, the effect of a single agent is restricted and the development of new combination treatments is urgently required.
胰腺癌是对化疗耐药的肿瘤之一。在本研究中，将人胰腺癌异种移植瘤（3例腺癌和1例囊腺癌）皮下移植到裸鼠体内，待肿瘤长至100 - 300立方毫米后，于第0、4和8天给小鼠腹腔注射丝裂霉素C（MMC）、阿霉素（ADR）、5 - 氟尿嘧啶（5 - FU）、卡波醌（CQ）、顺铂（CDDP）、盐酸尼莫司汀（ACNU）或DWA2114R，剂量为1/3半数致死量（LD50）。比较第12天的肿瘤大小与第0天的肿瘤大小。MMC和CQ显著抑制了3个细胞系的肿瘤生长，ACNU、CDDP和ADR抑制了1个细胞系的生长。此外，对移植了1个腺癌细胞系的小鼠口服给予5 - FU、替加氟、卡莫氟、优福定和苯丙氨酸氮芥（L - PAM）。虽然氟嘧啶类药物均未抑制肿瘤生长，但4毫克/千克的L - PAM显著抑制了肿瘤生长，不过同时伴有严重的体重减轻。在本研究中，几种药物显著抑制了肿瘤生长，但单独使用时均不能使肿瘤消退。这些结果表明，CQ、ACNU、CDDP和L - PAM可能适用于胰腺癌的化疗。然而，单一药物的效果有限，迫切需要开发新的联合治疗方法。
