Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 9420 Athena Circle Drive, La Jolla, CA 92037, USA.
Immunity. 2010 Jul 23;33(1):7-9. doi: 10.1016/j.immuni.2010.07.012.
The chemokine receptor CXCR2 binds several chemokines, some of them with functions yet to be defined. In this issue of Immunity, Mei et al. (2010) generated CXCL5-deficient mice and described a prominent role of CXCL5 in the regulation of CXCR2-dependent neutrophil trafficking during pulmonary host defense.
趋化因子受体 CXCR2 结合几种趋化因子，其中一些趋化因子的功能尚未确定。在本期《免疫》杂志中，Mei 等人（2010）生成了 CXCL5 缺陷型小鼠，并描述了 CXCL5 在调节肺部宿主防御中 CXCR2 依赖性中性粒细胞迁移中的重要作用。
