Eskelinen M, Hippeläinen M, Carlsson L, Jonsson P
Department of Surgery, University of Kuopio, Finland.
Anticancer Res. 1991 Mar-Apr;11(2):805-8.
The aim of the present study was to evaluate the clinical value of the new tumour marker TAG 12 in sera from patients with breast cancer, patients with benign breast disease and normal controls. The results for TAG 12 were compared with those for CA 15-3 and MCA. The cut-off levels (95th percentile) determined for each test in the benign and control groups were 59 KU/l for TAG 12, 27 KU/l for CA 15-3 and 12 KU/l for MCA. The diagnostic sensitivity of the TAG 12 test was 0.30 (cut-off level 59 KU/l), 0.25 for CA 15-3 test (cut-off level 27 KU/l) and 0.15 for MCA test (cut-off level 12 KU/l) in detecting breast cancer. The combination of TAG 12, CA 15-3 and MCA reached the diagnostic sensitivity 0.35, specificity 0.90, efficiency 0.68, LR+ 3.5, and LR- 0.72 The correlation coefficient in breast cancer patients between TAG 12 and CA 15-3 was 0.99 and the correlation coefficient between TAG 12 and MCA was 0.95. In conclusion, the results indicate that TAG 12, CA 15-3 and MCA have only limited value in the diagnosis of breast cancer, but their role in monitoring and follow-up of breast cancer patients is a subject for further investigation.
本研究的目的是评估新型肿瘤标志物TAG 12在乳腺癌患者、乳腺良性疾病患者及正常对照者血清中的临床价值。将TAG 12的检测结果与CA 15-3和MCA的检测结果进行比较。在良性组和对照组中，每项检测确定的临界值（第95百分位数）分别为：TAG 12为59 KU/l，CA 15-3为27 KU/l，MCA为12 KU/l。在检测乳腺癌时，TAG 12检测的诊断敏感性为0.30（临界值59 KU/l），CA 15-3检测为0.25（临界值27 KU/l），MCA检测为0.15（临界值12 KU/l）。TAG 12、CA 15-3和MCA联合检测的诊断敏感性为0.35，特异性为0.90，效率为0.68，阳性似然比为3.5，阴性似然比为0.72。乳腺癌患者中TAG 12与CA 15-3的相关系数为0.99，TAG 12与MCA的相关系数为0.95。总之，结果表明TAG 12、CA 15-3和MCA在乳腺癌诊断中的价值有限，但其在乳腺癌患者监测和随访中的作用有待进一步研究。
