Eskelinen M, Hippeläinen M, Salmela E, Paajanen H, Alhava E, Syrjänen K
Department of Surgery, University of Kuopio, Finland.
Anticancer Res. 1992 Nov-Dec;12(6B):2033-6.
The aim of the present study was to evaluate the clinical value of a new tumour marker TPS in sera from patients with breast cancer and patients with benign breast disease. The results for TPS were compared with those for TAG 12, CA 15-3 and MCA. The cutoff levels (90% specificity) determined for each test were 108.0 U/1 for TPS, 57.5 KU/1 for TAG 12, 24.8 KU/1 for CA 15-3 and 9.7 KU/1 for MCA. The diagnostic sensitivity of the TPS test was 0.21, for the TAG 12 test it was 0.2, 0.13 for the CA 15-3 test and 0.12 for the MCA test in detecting breast cancer. TPS, TAG 12, CA 15-3 and MCA tests were tested in a multivariate analysis to find the best combination of independent predictors of breast cancer. The most important predictor of breast cancer was TAG 12 followed by TPS. In order to calculate the contributions of tumour marker tests, a diagnostic score (DS) was developed. The diagnostic score (DS) was: DS = TPS x 0.0085 x TAG 12 x 0.0596 - CA 15-3 x 0.0866 - MCA x 0.2938 + 0.1738. The sensitivity of the DS in detecting breast cancer was 55% with a specificity of 90% and an efficiency of 64%. In conclusion, new tumour markers TPS and TAG 12 may have some value in breast cancer diagnosis. In particular, the results indicate the usefulness of computer assistance and a simple diagnostic score when tumour markers are used in breast cancer diagnosis.
本研究的目的是评估一种新的肿瘤标志物TPS在乳腺癌患者和乳腺良性疾病患者血清中的临床价值。将TPS的检测结果与TAG 12、CA 15-3和MCA的检测结果进行比较。每项检测确定的临界值（特异性90%）分别为：TPS为108.0 U/1，TAG 12为57.5 KU/1，CA 15-3为24.8 KU/1，MCA为9.7 KU/1。TPS检测在检测乳腺癌时的诊断敏感性为0.21，TAG 12检测为0.2，CA 15-3检测为0.13，MCA检测为0.12。对TPS、TAG 12、CA 15-3和MCA检测进行多变量分析，以找出乳腺癌独立预测指标的最佳组合。乳腺癌最重要的预测指标是TAG 12，其次是TPS。为了计算肿瘤标志物检测的贡献，制定了一个诊断评分（DS）。诊断评分（DS）为：DS = TPS×0.0085×TAG 12×0.0596 - CA 15-3×0.0866 - MCA×0.2938 + 0.1738。DS检测乳腺癌的敏感性为55%，特异性为90%，效率为64%。总之，新的肿瘤标志物TPS和TAG 12在乳腺癌诊断中可能具有一定价值。特别是，结果表明在乳腺癌诊断中使用肿瘤标志物时，计算机辅助和简单的诊断评分是有用的。
