Department of Genetic Epidemiology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany.
Schizophr Res. 2010 Sep;122(1-3):24-30. doi: 10.1016/j.schres.2010.06.018. Epub 2010 Jul 19.
The aim of the present study was to investigate possible associations between schizophrenia and 13 SNP markers in COMT. No association was observed in 631 cases, 207 nuclear families, and 776 controls. A cognitive performance phenotype (Trail Marking Test) was available for a subgroup of the patients. No association was found between the 13 markers and this phenotype. Four clinically-defined subgroups (early age at onset, negative symptoms, family history of schizophrenia, and life-time major depressive episode) were also investigated. Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population.
本研究旨在探讨 COMT 中 13 个 SNP 标记与精神分裂症之间可能存在的关联。在 631 例病例、207 个核心家庭和 776 名对照中未观察到关联。患者的亚组可获得认知表现表型（Trail Marking Test）。未发现这 13 个标记与该表型之间存在关联。还研究了四个临床定义的亚组（发病年龄早、阴性症状、精神分裂症家族史和终生重性抑郁发作）。其中 3 个亚组存在关联，但均未通过多重检验校正。在该人群中，COMT 似乎不是精神分裂症的危险因素。
