Otti A, Gündel H, Wohlschläger A, Zimmer C, Sorg C, Noll-Hussong M
Abteilung für Neuroradiologie, Klinikum rechts der Isar, Technische Universität München.
Nervenarzt. 2012 Jan;83(1):16, 18-24. doi: 10.1007/s00115-011-3307-6.
The resting state of the human brain is intrinsically organized by the so-called default mode network (DMN) which comprises cortical midline structure as well as lateral parietal and temporal areas. The activity of this system increases during self-oriented thinking, e.g. during a resting state but decreases during externally oriented attention and specific cognitive tasks. This review article provides a historical and methodological outline of the DMN model and describes its functional anatomy and putative functions. Based on the empirical literature the clinical implications of alterations of the DMN architecture and its role in various mental disorders are discussed.
人类大脑的静息状态由所谓的默认模式网络（DMN）内在地组织起来，该网络包括皮质中线结构以及外侧顶叶和颞叶区域。在自我导向思维过程中，例如在静息状态下，这个系统的活动会增加，但在外部导向注意力和特定认知任务期间会减少。这篇综述文章提供了DMN模型的历史和方法概述，并描述了其功能解剖结构和假定功能。基于实证文献，讨论了DMN结构改变的临床意义及其在各种精神障碍中的作用。
