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肺叶切除术中肌肉保留与后外侧开胸手术的对比:随机对照试验

Muscle sparing versus posterolateral thoracotomy for pulmonary lobectomy: randomised controlled trial.

作者信息

Nosotti Mario, Baisi Alessandro, Mendogni Paolo, Palleschi Alessandro, Tosi Davide, Rosso Lorenzo

机构信息

Thoracic Surgery and Lung Transplant Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Via Francesco Sforza, 35, 20122 Milan, Italy.

出版信息

Interact Cardiovasc Thorac Surg. 2010 Oct;11(4):415-9. doi: 10.1510/icvts.2010.238840. Epub 2010 Jul 19.

Abstract

Muscle sparing thoracotomy (MST) has been proposed as an alternative to posterolateral thoracotomy (PLT) for pulmonary lobectomy. This issue has been addressed by few clinical reports. To explore that subject, a prospective, controlled randomised, double-blind trial comparing MST through the auscultatory triangle and PLT was planned. The study included patients scheduled for pulmonary lobectomy for stage I or II non-small-cell lung cancer and were followed for three years. The primary endpoints were pain, analgesic consumption and post-thoracotomy pain syndrome. The secondary endpoints included morbidity plus shoulder and pulmonary functions. The trial randomised 100 patients into two groups. Postoperative pain results were similar, although analgesic consumption was higher in the PLT group (P=0.001). The MST group had a shorter hospital stay (P=0.003). Three years post-thoracotomy syndrome was unaffected by the type of incision. The women suffered more than men during the early and late postoperative time. An inverse correlation between incision length and pain was found. Immediate shoulder strength was significantly better in the MST group (P=0.004) but postoperative pulmonary function and complications were comparable. The two incisions results were very similar in the patient outcome, however, few aspects indicated the MST as the more suitable incision for pulmonary lobectomy.

摘要

肌肉保留开胸术(MST)已被提议作为肺叶切除术的后外侧开胸术(PLT)的替代方法。这一问题很少有临床报告涉及。为探讨该主题,计划进行一项前瞻性、对照随机双盲试验,比较经听诊三角的MST和PLT。该研究纳入计划接受I期或II期非小细胞肺癌肺叶切除术的患者,并随访三年。主要终点是疼痛、镇痛药用量和开胸术后疼痛综合征。次要终点包括发病率以及肩部和肺功能。该试验将100名患者随机分为两组。术后疼痛结果相似,尽管PLT组的镇痛药用量更高(P = 0.001)。MST组的住院时间更短(P = 0.003)。开胸术后三年综合征不受切口类型影响。女性在术后早期和晚期比男性遭受的痛苦更多。发现切口长度与疼痛呈负相关。MST组的即时肩部力量明显更好(P = 0.004),但术后肺功能和并发症相当。然而,在患者预后方面,两种切口的结果非常相似,不过有几个方面表明MST是更适合肺叶切除术的切口。

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