West China Second University Hospital, Sichuan University, Chengdu, PR China.
Int J Environ Health Res. 2010 Aug;20(4):289-97. doi: 10.1080/09603121003663479.
Since 2008, the food safety issue of melamine poisoning has again become a health scare for children. The mechanism of how melamine initiates kidney stones and kidney-associated renal complications is still unknown. Some children who ingested melamine-contaminated powdered formula had leukocyturia, but none had typical symptoms of urinary tract infection. We believed that the children's immune systems might have some changes. We followed up 170 children who ingested melamine-contaminated powdered formula and tested their blood and urine and to observe their immune state, and also performed ultrasonography. In the immune responses of children with stones, immunoglobulin M takes a major immune response and the level of CD3(+), CD4(+) decreased compared with children without stones. There was no difference in complete blood count between the children with stones and those without stones. We concluded that leukocyturia had a certain relationship with non-urinary tract infectious renal disease and these children are susceptible to infectious diseases.
自 2008 年以来，三聚氰胺中毒的食品安全问题再次成为儿童健康的一大隐患。三聚氰胺引发肾结石和肾脏相关肾脏并发症的机制尚不清楚。一些摄入受三聚氰胺污染的配方奶粉的儿童出现白细胞尿，但没有典型的尿路感染症状。我们认为儿童的免疫系统可能发生了一些变化。我们对 170 名摄入受三聚氰胺污染配方奶粉的儿童进行了随访，检测了他们的血液和尿液，观察他们的免疫状态，并进行了超声检查。在结石患儿的免疫反应中，免疫球蛋白 M 起主要免疫反应，与无结石患儿相比，CD3(+)、CD4(+)水平降低。结石患儿与无结石患儿的全血细胞计数无差异。我们得出结论，白细胞尿与非尿路感染性肾脏疾病有一定关系，这些儿童易患传染病。
